A new poll could spell big trouble for New York: Nearly four of every 10 voters here are thinking of fleeing. Their No. 1 reason: high taxes.

The survey, released this month by Zogby, found that 38.9% of voters are “considering” or already have “made plans” to head out, up five points from a month earlier. If even just half do, New York could lose millions of residents and enormous political clout, not to mention the tax revenue these folks pay.

Most notably, a stunning 36.7% say their top reason for wanting out is that taxes are “too high,” a gripe more people cited than any other. Even a quarter of “progressives,” 32% of “liberals” and 38% of “moderates” cite high taxes as their strongest motivation to leave.

Never mind the druggies and crazies, disastrous schools or even surging crime (though 48% say................