WASHINGTON — Hillary Clinton made it abundantly clear Wednesday night that if she defeats Donald J. Trump next month she will enter the White House with the most contentious relationship with Russia of any president in more than three decades, and with a visceral, personal animus toward Vladimir V. Putin, its leader.

“We haven’t seen a you-can’t-trust-these-guys tone like this since the days of Ronald Reagan,” said Stephen Sestanovich, who served in President Bill Clinton’s State Department and is the author of “Maximalist: America in the World from Truman to Obama.” “But even that was more a systemic criticism of the Soviet Union. This is focused on Putin himself.”

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